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KMID : 1007520190280041177
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Food Science and Biotechnology
2019 Volume.28 No. 4 p.1177 ~ p.1186
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The ameliorative effect of Protaetia brevitarsis Larvae in HFD-induced obese mice
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Ahn Eun-Mi
Myung Noh-Yil
Jung Hyeon-A
Kim Su-Jin
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Abstract
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Protaetia brevitarsis Lewis (P. brevitarsis) larvae, edible insect, traditionally is consumed for various health benefits. However, little information is available with respect to its direct anti-obesity effects. Thus, the present study was designed to investigate the regulatory effect of P. brevitarsis against high-fat diet (HFD)-induced obese mice. HFD-fed mice showed an increase in the body weight and serum levels of total cholesterol as well as low-density lipoprotein-cholesterol, and triglycerides. The administration of P. brevitarsis to obese mice induced a reduction in their body weight, lipid accumulation in liver and serum lipid parameter compared with the HFD fed mice. P. brevitarsis also inhibited the expression of obesity-related genes such as CCAAT/enhancer-binding protein alpha and fatty acid synthesis in 3T3-L1 cells. Moreover, oleic acid was identified as predominant fatty acid of P. brevitarsis by gas chromatography analysis. Conclusively, these findings suggested that P. brevitarsis may help to prevent obesity and obesity-related metabolic diseases.
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KEYWORD
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Protaetia brevitarsis Lewis, Edible insect, Obesity, High-fat diet, Oleic acid
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